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Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. Johnston BC, Kanters S, Bandayrel K, Wu P, Naji F, Siemieniuk RA, Ball GDC, Busse JW, Thorlund K, Guyatt G, Jansen JP, Mills EJ. Long-term effects of advice to consume a high-protein, low-fat diet, rather than a conventional weight-loss diet, in obese adults with type 2 diabetes: one-year follow-up of a randomised trial. The connectivity of each network meta-analysis was described using density, which was calculated as the ratio of the number of treatment pairs with head-to-head evidence over the total number of treatment pairs. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus. Accessibility verified August 4, 2014. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. gov and the metaRegister of Controlled Trials. Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs reduced carbohydrate diets. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. 9, Author Audio Interview. How to use an article reporting a multiple treatment comparison meta-analysis. Quiz Ref ID Network meta-analysis facilitates comparison of different diets using all available randomized clinical trial (RCT) data. Otherwise, we used the pre- and postintervention standard deviations along with a correlation estimated from studies that reported both change and pre- and postintervention results. Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects. Dietary guidelines for Americans: 2010. GRADE overall confidence in estimates: 12-month weight loss eTable 13. Summary of risk of bias by diet class and brand eTable 3. Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects. We contacted the named diet companies and individuals working in the field of obesity and weight management to identify additional or unpublished trials. Effects of two weight-loss diets on health-related quality of life. Search of 6 electronic databases: AMED, CDSR, CENTRAL, CINAHL, EMBASE, and MEDLINE from inception of each database to April 2014. A Bayesian framework was used to perform a series of random-effects network meta-analyses with meta-regression to estimate the relative effectiveness of diet classes and programs for change in weight and body mass index from baseline. 13 We assigned 1 of 2 summary assessments for each included study: low risk of bias for key domains, allocation concealment, and missing participant data or high risk of bias for key domains. Because it is impossible to provide a placebo diet in a clinical trial, eligible control diets included wait-listed controls, no specific assigned diet, or competing dietary programs. For example, the Atkins diet resulted in a 1. We searched 6 electronic databases: AMED, CDSR, CENTRAL, CINAHL, EMBASE, and MEDLINE from inception of each database to April 2014. Improved psychological well-being, quality of life, and health practices in moderately overweight women participating in a 12-week structured weight loss program. Weight loss with self-help compared with a structured commercial program: a randomized trial. Publication bias assessed via funnel plots—Atkins versus moderate micronutrient diets: 6-month weight loss eFigure 5. 12. 1 Debate regarding the relative merit of the diets is accompanied by advertising claiming which macronutrient composition is superior, such as a low-carbohydrate diet being better than a low-fat diet, and the benefits of accompanying lifestyle interventions. Lifestyle Behaviors Nutrition Obesity Shared Decision Making and Communication Treatment Adherence Diet. Risk of bias versus quality assessment of randomised controlled trials: cross sectional study. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A to Z Weight Loss Study: a randomized trial. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when restricted to low risk of bias studies eTable 5. I do try to give all the info I can but sometimes my delivery is harsh due to my frustration. Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects. JAMA 2014-09-02, Vol. Weight loss differences between individual diets were minimal. When I read a post saying that someone tried bananas for the tingling and it worked - well, it just makes me stupidly happy. Self-help weight loss versus a structured commercial program after 26 weeks: a randomized controlled study. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. Difference in mean decrease in BMI at 6 and 12 months across diet classes with 95% credible intervals eTable 14. GRADE guidelines: 3, rating the quality of evidence. Long-term effects of a very low-carbohydrate diet and a low-fat diet on mood and cognitive function. Dietary protein and exercise have additive effects on body composition during weight loss in adult women. Named diets were identified through the explicit naming of the brand, the referencing of branded literature, or the naming of a brand as funders of an article reporting weight loss outcomes from the diet. Branded diets and weight loss in overweight or obese adults: a network meta-analysis. In the latter cases, transformations were used to express weight loss and BMI as mean change. Network diagrams for randomized controlled trials investigating change in BMI among diets, categorized by diet class eFigure 6. For example, dietary programs that did not refer to Atkins but consisted of less than 40% of kilocalories from carbohydrates per day for the duration of study or were funded by Atkins were considered Atkins-like. Effects of energy-restricted diets containing increased protein on weight loss, resting energy expenditure, and the thermic effect of feeding in type 2 diabetes. Lifestyle intervention in overweight individuals with a family history of diabetes. Effect of a free prepared meal and incentivized weight loss program on weight loss and weight loss maintenance in obese and overweight women: a randomized controlled trial. This way of thinking is counter productive and dangerous in some cases. A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women. 312, No. Analyses were conducted using 6- and 12-month data, with a 3-month window (eg, if a study reported weight loss at 5 months, it was used in the 6-month analysis). Combining behavioral weight loss treatment and a commercial program: a randomized clinical trial. These programs represent a multibillion dollar industry. Supplement. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for proportion female (continuous measure) eTable 8. Some physiological explanations regarding the merits of different macronutrient compositions, including variable genetic response to diets with different recommended dietary fat intake, make intuitive sense. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for percentage loss to follow-up (continuous measure) eTable 6. Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults A Meta-analysis. :). Network diagrams for randomized controlled trials investigating change in BMI among branded and common diets. By not exploring the full range of potential comparisons in a statistically and methodologically rigorous fashion, these reviews could have missed important benefits of specific diets or their compositions. Dietary energy density in the treatment of obesity: a year-long trial comparing 2 weight-loss diets. Named or branded (trade-marked) weight loss programs are broadly available to the general public, providing structured dietary and lifestyle recommendations via popular books and in-person or online behavioral support. Comparison of range of commercial or primary care led weight reduction programmes with minimal intervention control for weight loss in obesity: lighten up randomised controlled trial. A low-carbohydrate as compared with a low-fat diet in severe obesity. For our branded diet analysis, we made a visual assessment of funnel plots for publication bias for direct comparisons that included 10 or more studies. Effects of a low-intensity intervention that prescribed a low-carbohydrate vs a low-fat diet in obese, diabetic participants. A detailed description of the statistical analysis appears in the eMethods in the Supplement. Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning. Of the total, 889 proved potentially relevant for full-text review and 59 articles that reported 48 RCTs of 11 branded diets proved eligible (eFigure 1 in the Supplement ). GRADE confidence in direct estimates: 12-month weight loss eTable 11. Network diagrams for randomized controlled trials investigating weight loss among branded diets eFigure 4. Many claims have been made regarding the superiority of one diet or another for inducing weight loss. Effects of a low carbohydrate weight loss diet on exercise capacity and tolerance in obese subjects. 9, 10, 17, 18, 22 -. Difference in mean decrease in BMI at 6 and 12 months across diet brands with 95% credible intervals eTable 15. Quiz Ref ID Despite potential biological mechanisms explaining why some popular diets should be better than others, recent reviews suggest that most diets are equally effective, 2, 5, 6 a message very different from what the public hears in advertisements or expert pronouncements. Honestly, I feel that it is my duty to give out the information that I have. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. Stern. Two reviewers independently extracted data on populations, interventions, outcomes, risk of bias, and quality of evidence. Nondieting versus dieting treatment for overweight binge-eating women. We included RCTs that reported weight loss or BMI reduction at 3-month follow-up or longer. I only started losing a little weight at 75 mg. The effect of a low-carbohydrate, high-protein diet on post laparoscopic gastric bypass weight loss: a prospective randomized trial. I heard the weightloss effect depends on the dose. Significant weight loss was observed with any low-carbohydrate or low-fat diet. View Large Download Diet Classes Based on Macronutrient Composition Table 2. Establishing which of the major named diets is most effective is important because overweight and obese patients often want to know which diet results in the most effective weight loss. Pairs of reviewers independently assessed the risk of bias associated with individual trials using the Cochrane Collaboration instrument.


The effects of a commercially available weight loss program among obese patients with type 2 diabetes: a randomized study. 12. In the case of percentage change, we assumed independence. Combining weight-loss counseling with the Weight Watchers plan for obese breast cancer survivors. When available, we used P values for group differences to derive the standard deviation of change from baseline. Dieting and the development of eating disorders in obese women: results of a randomized controlled trial. eTable 1. A self-regulation program for maintenance of weight loss. Network diagrams for randomized controlled trials investigating weight loss among diets, categorized by diet class eFigure 3. Long-term weight loss after diet and exercise: a systematic review. Exercise was defined as having explicit instructions for weekly physical activities and simply dichotomized when differences between varying degrees of exercise frequencies appeared to have negligible effects. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada. The search strategy is available from the authors upon request. 4. I do try to give all the info I can but sometimes my delivery is harsh due to my frustration. Your honesty, sense of humor and obvious knowledge of this drug was a joy to read. Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial. Your honesty, sense of humor and obvious knowledge of this drug was a joy to read. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Key differences between this analysis and recent joint guidelines from the American Heart Association (AHA), American College of Cardiology (ACC), and The Obesity Society (TOS) eFigure 1. A 12-week commercial web-based weight-loss program for overweight and obese adults: randomized controlled trial comparing basic versus enhanced features. Difference in mean weight loss at 6 and 12 months across all diet classes with 95% credible intervals when adjusting for baseline weight (overweight to obese vs morbidly obese) eTable 7. 2, 3 Low-carbohydrate diets may drive weight loss due to a higher intake of protein, which may induce a stronger satiating effect than fats and carbohydrates. Psychological benefits of a high-protein, low-carbohydrate diet in obese women with polycystic ovary syndrome—a pilot study. Weight, protein, fat, and timing of preloads affect food intake. The 48 RCTs included 7286 individuals with a median age of 45. :). The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets. I only started losing a little weight at 75 mg. GRADE confidence in indirect estimates: 12-month weight loss eTable 12. This supports the practice of recommending any diet that a patient will adhere to in order to lose weight. Thank you for being so understanding and kind. A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults. Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Accessed July 30, 2014. Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial. Diet classes were established by macronutrient content ( Table 1 ). When I was dx with Migraines I was taking a sub-lingual pill called Maxalt (this does work) you have to take one tablet and place it under your tongue as you feel a migraine coming on. To determine weight loss outcomes for popular diets based on diet class (macronutrient composition) and named diet. 71 kg greater weight loss than the Zone diet at 6-month follow-up. Random-effects pairwise meta-analyses (using the method by DerSimonian and Laird 19 ) were used to determine direct and indirect associated treatment effects for all network meta-analyses. The effects of an intensive lifestyle modification program on carotid artery intima-media thickness: a randomized trial. Good luck with your weight loss and also for I commend you for being a care giver. It will help lessen the pain with the migraine or sometimes will stop it. A randomized trial of a low-carbohydrate diet for obesity. Description of dietary programs eTable 2. The hazards of scoring the quality of clinical trials for meta-analysis. Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors. We considered 3 weight loss effect modifiers that were modeled as present or absent if they were included in an overall dietary program: calorie restriction, exercise, and behavioral support. Weight loss differences between individual named diets were small. Randomized trial of a multifaceted commercial weight loss program. GRADE guidelines: 4, rating the quality of evidence—study limitations (risk of bias). Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Screening for obesity in adults: recommendations and rationale. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. Using a network meta-analytic approach, we assessed the relative effectiveness of different popular diets in improving weight loss. 7 In the absence of published head-to-head clinical trials of each diet against each other diet, network meta-analysis uses both direct and indirect clinical trial evidence to estimate their relative effects. US Preventive Services Task Force. Reviewers, in pairs, independently screened titles and abstracts of articles and reviewed the full text of any title or abstract deemed potentially eligible by either reviewer. The diet was labeled as brand-like when the diet met the definition of a branded diet, but failed to name or reference the brand in the article. Difference in mean weight loss at 6 and 12 months across all diet brands with 95% credible intervals when restricted to low risk of bias studies eTable 10. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. We reviewed bibliographies of review articles and eligible trials, and searched the registries of ClinicalTrials. But I wish the manufacture would just change the taste of the pill, its fast dissolve and strong peppermint taste. Our analyses adjusted for behavioral support and exercise. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. JAMA 2014-09-02, Vol. Effects of hypocaloric diet, low-intensity resistance exercise with slow movement, or both on aortic hemodynamics and muscle mass in obese postmenopausal women. 7 years (median SD, 9 years), median weight of 94. Pairs of reviewers independently, and in duplicate, extracted the following data items: study setting, type of trial (parallel or factorial), demographic information, experimental interventions, control interventions, exercise information, degree of calorie restriction, degree of behavioral support, and each of the outcomes of interest. 9, 10. Comparative study of the effects of a 1-year dietary intervention of a low-carbohydrate diet versus a low-fat diet on weight and glycemic control in type 2 diabetes. Moderate carbohydrate, moderate protein weight loss diet reduces cardiovascular disease risk compared to high carbohydrate, low protein diet in obese adults: a randomized clinical trial. Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation. Good luck with your weight loss and also for I commend you for being a care giver. 14. Honestly, I feel that it is my duty to give out the information that I have. We categorized dietary treatment groups in 2 ways: using diet classes (moderate macronutrient distribution, low carbohydrate, and low fat) 15 and according to diet brands. Thank you for being so understanding and kind. Diets with at least 2 group or individual sessions per month for the first 3 months were considered as providing behavioral support. eMethods. 312, No. A randomized controlled trial of a commercial Internet weight loss program. When I read a post saying that someone tried bananas for the tingling and it worked - well, it just makes me stupidly happy. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. The characteristics of eligible branded dietary programs are reported in eTable 1 in the Supplement. Eligible programs included meal replacement products but had to consist primarily of whole foods and could not include pharmacological agents. Continuous outcomes were most often reported as mean change, but sometimes were reported as preintervention and postintervention measures or percentage change. 9. They also relied on aggregating studies comparing one diet with another and did not have the ability to determine the relative performance of diets when they were not directly compared with one another in clinical trials. I have been fighting Migraines for the last 6 years mostly caused from stress from work. 9, Author Audio Interview. Effects of a low-glycemic load vs low-fat diet in obese young adults: a randomized trial. Search terms included extensive controlled vocabulary and keyword searches for (RCTs) AND (diets) AND (adults) AND (weight loss). Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects. Systematic review: an evaluation of major commercial weight loss programs in the United States. The gray literature search identified 213 additional articles. Short-term effects of severe dietary carbohydrate-restriction advice in type 2 diabetes—a randomized controlled trial. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. Only a few of the reviews of named diets have used rigorous meta-analytic techniques to provide quantitative estimates of how much better one diet is compared with another.

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